Genobalance

연구 데이터 기반 건강과학 & 영양정보 블로그

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장내 미생물 검사, 받아볼까? 사기 전에 5가지만

장내 미생물 검사 광고 보고 고민 중이신가요? 어떤 사람에게 도움이 되고 어떤 사람에게 돈이 아까운지, 사기 전에 알아두면 좋은 5가지를 짧게 정리했습니다.

8/10

유산균 먹는데 효과를 모르겠다면 — 4주 확인법

유산균을 몇 달째 먹는데 효과가 있는 건지 없는 건지 애매하다면. 효과를 어떻게 확인하고, 언제까지 먹어봐야 하고, 언제 바꿔야 하는지 짧게 정리했습니다.

8/10

Why Single-Variant Pharmacogenomics Is Misleading: Star Alleles, Diplotypes, and What DTC Arrays Miss

A confident pharmacogenomics result from a single SNP looks reassuring and is often wrong. Real PGx is diplotype (star-allele) calling, and consumer genotyping arrays like 23andMe can't do it reliably. Here's why single-variant annotation misleads, which genes you can and can't trust from array data, and what a defensible PGx tool actually has to do.

6/23

ClinVar Variant Pathogenicity Lookup in Python — Programmatic Access for Hereditary Disease Screening (2026)

Step-by-step Python tutorial: query NCBI ClinVar via E-utilities API to get pathogenicity classification (Pathogenic, Likely Benign, VUS) for any SNP or variant. Useful for batch-screening 23andMe / WGS data against BRCA, Lynch syndrome, hereditary cancer panels, and any clinically annotated variant set.

5/27

Extracting CYP2C19 Star Alleles from 23andMe — Plavix (Clopidogrel) Response Prediction in Python

Python tutorial: parse 23andMe raw data for CYP2C19 *2, *3, and *17 variants, predict your clopidogrel (Plavix) response phenotype, and understand why ~20% of Koreans get suboptimal antiplatelet protection on standard dosing. Includes the SNP-to-star-allele lookup, phenotype interpretation, and where DTC data falls short.

5/27

Reading 23andMe Raw Data for CYP2D6 Star Alleles in Python — Why DTC Often Misses *5 Deletion

Step-by-step Python tutorial: parse a 23andMe raw data file, look up CYP2D6 star alleles from SNPs, and understand why some clinically important variants (like CYP2D6 *5 whole-gene deletion) are invisible to SNP-based DTC testing. Includes code for *2, *3, *4, *6, *10, *17 detection and a guide to which alleles you can and can't catch.

5/23